Therapeutic effects of Saireito (TJ-114), a traditional Japanese herbal medicine, on postoperative edema and inflammation after total hip arthroplasty.

Abstract

Saireito (TJ-114) is a traditional Japanese herbal medicine that has been used for treating edema and inflammation in diseases such as nephritic disease. This study investigates the effect of TJ-114 on postoperative edema and inflammation after total hip arthroplasty (THA). Patients who underwent cementless THA were randomly divided into two groups: Group A consisted of 8 hips of 8 patients who were treated with TJ-114 at a dose of 9 g/day 2 days before surgery and for 2 weeks after surgery; Group B consisted of 9 hips of 9 patients who did not take TJ-114. Although no significant difference was observed between the two groups for lower extremity edema, it was found that swelling of the proximal leg in Group A was less than that in Group B. Furthermore, 3 weeks after surgery, every measuring point in the lower extremity showed that TJ-114 tended to decrease postoperative swelling compared to measurements of swelling of patients who did not take TJ-114. Serum C-reactive protein (CRP) levels of 6 out of 8 patients in Group A decreased and became negative 2 weeks after surgery; however, there were no patients in Group B whose CRP levels became negative after 2 weeks. In conclusion, TJ-114 is safe and useful for the prevention and early recovery of postoperative leg edema after THA with an association of rapid CRP reduction.

• Authors: Y Kishida, H Miki, T Nishii, T Inoue, S Nishida, H Yoshikawa, N Sugano
• Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 14 Issue 9 Pg. 581-6 (Sep 2007) ISSN: 0944-7113 [Print] Germany
• PMID: 17292595 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drugs, Chinese Herbal
• sairei-to
• C-Reactive Protein

Topics

• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Arthroplasty, Replacement, Hip (adverse effects)
• C-Reactive Protein
• Drugs, Chinese Herbal (administration & dosage, therapeutic use)
• Edema (blood, etiology, pathology, prevention & control)
• Female
• Humans
• Japan
• Medicine, East Asian Traditional
• Middle Aged
• Phytotherapy
• Plants, Medicinal
• Postoperative Complications (blood, pathology, prevention & control)
• Severity of Illness Index
• Treatment Outcome