Results of a phase I clinical study using dendritic cell vaccinations for thyroid cancer.

Abstract

OBJECTIVE:

We assessed the feasibility and efficacy of dendritic cell (DC) therapy for advanced thyroid papillary and follicular cancer.

DESIGN:

Six Japanese patients (2 men and 4 women; aged 46-72 years, mean 60 years), who were diagnosed as advanced thyroid cancer with refractory distant metastases (papillary, n=5; follicular, n=1), were enrolled. Patients were first vaccinated weekly for 4 weeks with 10(7) autologous tumor lysate-pulsed monocyte-derived mature DCs followed by fortnightly vaccinations for 8 weeks (total=8 vaccinations). Lowdose (350 KIU) interleukin-2 was also administered for 3 days at each vaccination. Clinical response, adverse effects, delayed-type hypersensitivity skin testing (DTH), and IFN-( ) production by peripheral CD3(+) lymphocytes were evaluated.

MAIN OUTCOME:

Of the 6 patients, disease was assessed as stable in 2 and as progressive in 4. No adverse events were observed. Results of DTH and IFN-( ) production in peripheral lymphocytes did not correlate to the clinical response.

CONCLUSIONS:

DC immunotherapy could be administered to patients with thyroid papillary or follicular cancer without substantial side effects.

• Authors: Koichiro Kuwabara, Toshihide Nishishita, Mariko Morishita, Naoki Oyaizu, Shunichi Yamashita, Takashi Kanematsu, Takao Obara, Yoshikazu Mimura, Yusuke Inoue, Michio Kaminishi, Kimitaka Kaga, Nobuyuki Amino, Masafumi Kitaoka, Koichi Ito, Akira Miyauchi, Shiro Noguchi, Kaoru Uchimaru, Eiji Akagawa, Nobukazu Watanabe, Tsuneo A Takahashi, Kaori Sato, Takeshi Inazawa, Takashi Nakaoka, Naohide Yamashita
• Journal: Thyroid : official journal of the American Thyroid Association (Thyroid) Vol. 17 Issue 1 Pg. 53-8 (Jan 2007) ISSN: 1050-7256 [Print] United States
• PMID: 17274750 (Publication Type: Clinical Trial, Phase II, Journal Article)

Chemical References

• Cancer Vaccines

Topics

• Aged
• Cancer Vaccines (administration & dosage, adverse effects)
• Carcinoma, Papillary, Follicular (immunology, secondary, therapy)
• Cells, Cultured
• Dendritic Cells (cytology, immunology, transplantation)
• Female
• Humans
• Lung Neoplasms (immunology, secondary, therapy)
• Male
• Middle Aged
• Monocytes (cytology)
• Thyroid Neoplasms (immunology, pathology, therapy)
• Treatment Outcome