Convallasaponin A, a new 5beta-spirostanol triglycoside from the rhizomes of Convallaria majalis.

Abstract

The rhizomes of Convallaria majalis have been analyzed for their steroidal glycoside constituents, resulting in the isolation of a new 5beta-spirostanol triglycoside, named convallasaponin A, along with two known cardenolide glycosides and a known cholestane glycoside. The structure of convallasaponin A was determined on the basis of extensive spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage. The cardenolide glycosides showed tumor specific cytotoxic activity.

• Authors: Taro Higano, Minpei Kuroda, Hiroshi Sakagami, Yoshihiro Mimaki
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 55 Issue 2 Pg. 337-9 (Feb 2007) ISSN: 0009-2363 [Print] Japan
• PMID: 17268112 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Glycosides
• Spirostans
• convallasaponin A

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Convallaria (chemistry)
• Glycosides (chemistry, isolation & purification, pharmacology)
• Humans
• Hydrolysis
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Plants, Medicinal (chemistry)
• Spirostans (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured (drug effects)