Abstract | OBJECTIVE: The authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects. METHOD: Data were analyzed for 172 panic disorder patients who were randomly assigned to receive imipramine alone, imipramine plus CBT, or placebo. Mixed-effects models were used to assess longitudinal differences among the treatment groups with respect to side effect burden and dropout rates during the acute, maintenance, and follow-up phases of treatment. RESULTS: Patients treated with imipramine plus CBT experienced less severe fatigue/weakness, dry mouth, and sweating and had a lower rate of dropout due to side effects compared with those treated with imipramine only. CONCLUSIONS: The addition of CBT to medication treatment with imipramine was associated with less severe side effects and fewer dropouts due to perceived side effects than treatment with imipramine alone.
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Authors | Sue M Marcus, Jack Gorman, M Katherine Shear, David Lewin, Jose Martinez, Susan Ray, Raymond Goetz, Serge Mosovich, Lauren Gorman, David Barlow, Scott Woods |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 164
Issue 2
Pg. 273-5
(Feb 2007)
ISSN: 0002-953X [Print] United States |
PMID | 17267790
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Antidepressive Agents, Tricyclic
- Placebos
- Imipramine
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Topics |
- Antidepressive Agents, Tricyclic
(adverse effects, therapeutic use)
- Cognitive Behavioral Therapy
- Combined Modality Therapy
- Fatigue
(chemically induced)
- Humans
- Hyperhidrosis
(chemically induced)
- Imipramine
(adverse effects, therapeutic use)
- Panic Disorder
(drug therapy, prevention & control, therapy)
- Patient Dropouts
(statistics & numerical data)
- Placebos
- Severity of Illness Index
- Sweating
(drug effects)
- Xerostomia
(chemically induced)
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