Safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated polio vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine.

Abstract	The safety of DTaP-HepB-IPV vaccine coadministered with PCV and Hib was compared with separate administration of DTaP, HepB, IPV, Hib, and PCV at 2, 4, and 6 months of age. Healthy 2-month-old infants (N=1008) were randomized to the two groups. Following dose 1, there was no significant difference between the groups in the incidence of fever >101.3 degrees F. After each dose, the incidence of any fever (> or =100.4 degrees F) was significantly higher in the Combination Vaccine Group. The rate of fever >103.1 degrees F was < or =1.4% in both groups after any of the doses. Medical advice visits for fever were infrequent in both groups (< or =1.2%). DTaP-HepB-IPV was safe and well tolerated when coadministered with PCV and Hib.
Authors	Susan Partridge, Justin Alvey, Henry Bernstein, Mark Blatter, Gerald Bottenfield, Juan Guerrero, Shelly D Senders, Lode Schuerman, Brigitte Cheuvart, Sandra J Holmes
Journal	Vaccine (Vaccine) Vol. 25 Issue 10 Pg. 1806-13 (Feb 26 2007) ISSN: 0264-410X [Print] Netherlands
PMID	17240493 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines Haemophilus influenzae type b polysaccharide vaccine Hepatitis B Vaccines Heptavalent Pneumococcal Conjugate Vaccine Meningococcal Vaccines Pneumococcal Vaccines Poliovirus Vaccine, Inactivated Polysaccharides, Bacterial Vaccines, Conjugate diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine
Topics	Bacterial Capsules Diphtheria-Tetanus-Pertussis Vaccine (adverse effects) Female Fever Haemophilus Vaccines (administration & dosage, adverse effects) Hepatitis B Vaccines (adverse effects) Heptavalent Pneumococcal Conjugate Vaccine Humans Infant Male Meningococcal Vaccines (administration & dosage, adverse effects) Pneumococcal Vaccines (administration & dosage, adverse effects) Poliovirus Vaccine, Inactivated (administration & dosage, adverse effects) Polysaccharides, Bacterial (administration & dosage, adverse effects) Vaccines, Conjugate (administration & dosage, adverse effects)

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