Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness.

Abstract

BACKGROUND:

Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer.

MATERIALS AND METHODS:

Syk expression in patients with invasive breast cancer was immunohistochemically assessed.

RESULTS:

Decreased expression was found in 26% of the specimens examined. In cases with vascular invasion, expression of Syk was lost in the intravascular emboli. A significant relationship between increased proliferation levels (as estimated by the proliferative index, Ki67) and decreased Syk expression (p <0.05) was found.

CONCLUSION:

Our data suggest that Syk protein expression inversely correlates with the proliferation and invasive capacity of breast cancer.

• Authors: Katerina Repana, Konstantinos Papazisis, Periklis Foukas, Rozalia Valeri, Alexandros Kortsaris, Eleni Deligiorgi, Dimitrios Kyriakidis
• Journal: Anticancer research (Anticancer Res) 2006 Nov-Dec Vol. 26 Issue 6C Pg. 4949-54 ISSN: 0250-7005 [Print] Greece
• PMID: 17214368 (Publication Type: Journal Article)

Chemical References

• Intracellular Signaling Peptides and Proteins
• Receptors, Interleukin-8A
• Receptors, Interleukin-8B
• Protein-Tyrosine Kinases
• SYK protein, human
• Syk Kinase

Topics

• Adult
• Aged
• Breast Neoplasms (enzymology, pathology)
• Breast Neoplasms, Male (enzymology, pathology)
• Cell Growth Processes (physiology)
• Female
• Humans
• Immunohistochemistry
• Intracellular Signaling Peptides and Proteins
• Male
• Middle Aged
• Neoplasm Invasiveness
• Protein-Tyrosine Kinases (biosynthesis)
• Receptors, Interleukin-8A (biosynthesis)
• Receptors, Interleukin-8B (biosynthesis)
• Syk Kinase