Abstract | BACKGROUND: OBJECTIVE: This study was designed to investigate the expression of phosphorylated p38 MAP kinasealpha (p-p38 MAPKalpha), phosphorylated NF-kappa B p65 (p-NF-kappaB p65) and cyclin D1 proteins in EMPD and to evaluate the relationship among them. METHODS: Thirty-five tissue samples from 30 primary EMPD cases were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections for p-p38 MAPKalpha, p- NF-kappaB p65 and cyclin D1. RESULTS: Among the 35 specimens of EMPD, p-p38 MAPKalpha, p- NF-kappaB p65 and cyclin D1 were expressed in 30, 28 and 27, respectively. Moreover, in five metastatic lymph node specimens, all were positive for p-p38 MAPKalpha and p- NF-kappaB p65, four were positive for cyclin D1. There were significant correlations between expression of p-p38 MAPKalpha, p- NF-kappaB p65, and cyclin D1 in EMPD. CONCLUSION:
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Authors | Nengxing Lin, Hiroshi Uchi, Yoichi Moroi, Noriko Fukiwake, Teruki Dainichi, Satoshi Takeuchi, Masakazu Takahara, Yating Tu, Masutaka Furue, Kazunori Urabe |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 45
Issue 3
Pg. 187-92
(Mar 2007)
ISSN: 0923-1811 [Print] Netherlands |
PMID | 17207971
(Publication Type: Journal Article)
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Chemical References |
- Cyclin D
- Cyclins
- Transcription Factor RelA
- p38 Mitogen-Activated Protein Kinases
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cyclin D
- Cyclins
(metabolism)
- Female
- Humans
- Immunohistochemistry
- MAP Kinase Signaling System
- Male
- Middle Aged
- Paget Disease, Extramammary
(metabolism, pathology)
- Skin Neoplasms
(metabolism, pathology)
- Transcription Factor RelA
(metabolism)
- p38 Mitogen-Activated Protein Kinases
(metabolism)
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