Antigen-specific T-lymphocyte function after cord blood transplantation.

Abstract

It has not been possible to determine the singular contribution of naive T lymphocytes to antigen-specific immunity after hematopoietic stem cell transplantation (HSCT), because of the confounding effects of donor-derived antigen-specific T lymphocytes present in most hematopoietic stem cell (HSC) products. Because umbilical cord blood contains only naive T lymphocytes, we longitudinally evaluated the recipients of unrelated cord blood transplantation (UCBT) for the presence of T lymphocytes with specificity for herpesviruses, to determine the contribution of the naive T lymphocytes to antigen-specific immune reconstitution after HSCT. Antigen-specific T lymphocytes were detected early after UCBT (herpes simplex virus on day 29; cytomegalovirus on day 44; varicella zoster virus on day 94). Overall, 66 of 153 UCBT recipients developed antigen-specific T lymphocytes to 1 or more herpesviruses during the evaluation period. The likelihood of developing antigen-specific T lymphocyte function was not associated with immunophenotypic T lymphocyte reconstitution, transplant cell dose, primary disease, or acute and chronic graft-versus-host disease. These results indicate that naive T lymphocytes present in the HSC inoculum can contribute to the generation of antigen-specific T-lymphocyte immunity early after transplantation.

• Authors: Geoff Cohen, Shelly L Carter, Kenneth I Weinberg, Bernadette Masinsin, Eva Guinan, Joanne Kurtzberg, John E Wagner, Nancy A Kernan, Robertson Parkman
• Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 12 Issue 12 Pg. 1335-42 (Dec 2006) ISSN: 1083-8791 [Print] United States
• PMID: 17162216 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antibodies, Viral

Topics

• Adolescent
• Antibodies, Viral (blood)
• Cell Lineage
• Child
• Child, Preschool
• Clinical Trials, Phase II as Topic (statistics & numerical data)
• Cord Blood Stem Cell Transplantation
• Cytomegalovirus (immunology, physiology)
• Cytomegalovirus Infections (diagnosis, immunology, prevention & control, virology)
• False Negative Reactions
• Female
• Fetal Blood (immunology)
• Follow-Up Studies
• Graft vs Host Disease (etiology, immunology)
• Herpes Simplex (diagnosis, immunology, prevention & control, virology)
• Herpes Zoster (diagnosis, immunology, prevention & control, virology)
• Herpesvirus 3, Human (immunology, physiology)
• Humans
• Infant
• Infant, Newborn
• Infections (immunology, mortality)
• Male
• Multicenter Studies as Topic (statistics & numerical data)
• Postoperative Complications (immunology, mortality)
• Postoperative Period
• Simplexvirus (immunology, physiology)
• T-Cell Antigen Receptor Specificity
• T-Lymphocyte Subsets (immunology)
• Time Factors
• Treatment Outcome
• Virus Activation