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[The use of electron microscopy for diagnosing spongiform encephalopathies].

Abstract
The authors suggest an unsophisticated approach to laboratory diagnosis of spongiform encephalopathies induced by unconventional prion viruses, consisting in electron microscopic detection of abnormal helical Scrapie-associated fibrils. These fibrils are detectable in human and animal brain tissue samples and in cell cultures.
AuthorsN N Poleshchuk, S P Kapitulets, Iu G Il'kevich, Z B Kvacheva
JournalLaboratornoe delo (Lab Delo) Issue 4 Pg. 42-4 ( 1991) ISSN: 0023-6748 [Print] Russia (Federation)
Vernacular TitleIspol'zovanie élektronnoĭ mikroskopii dlia diagnostiki spongioformnykh éntsefalopatiĭ.
PMID1715430 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Prions
Topics
  • Animals
  • Brain (ultrastructure)
  • Brain Diseases (microbiology, pathology)
  • Guinea Pigs
  • Humans
  • In Vitro Techniques
  • Microscopy, Electron
  • Prions
  • Virus Diseases (microbiology, pathology)

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