Abstract | OBJECTIVES: Previous studies on the association of fetal cell-free (cf) DNA levels in maternal circulation have produced conflicting results but the sample sizes were small and based on archived material. We aimed to quantify the levels of fetal and total cfDNA on prospectively collected samples, to understand their correlation with other variables and to clarify their diagnostic value. METHODS: RESULTS: Fetal cfDNA levels (DYS14) showed correlation with crown rump length (CRL) (p = 0.004), BMI (p = 0.01) and storage time (p = 0.007) while there was an inverse correlation of total cfDNA levels with nuchal translucency (NT) (p = 0.001). No significant difference was observed between the levels of fetal cfDNA in controls and aneuploidy cases. CONCLUSION: Quantification of fetal and total cfDNA in maternal circulation showed inverse correlation between NT and total cfDNA levels. Our results also suggest that fetal cfDNA is not an ideal prognostic marker for chromosomal abnormalities in first-trimester pregnancies.
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Authors | Ageliki Gerovassili, Chad Garner, Kypros H Nicolaides, Swee Lay Thein, David C Rees |
Journal | Prenatal diagnosis
(Prenat Diagn)
Vol. 27
Issue 2
Pg. 104-10
(Feb 2007)
ISSN: 0197-3851 [Print] England |
PMID | 17152117
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2006 John Wiley & Sons, Ltd. |
Chemical References |
- Biomarkers
- SRY protein, human
- Sex-Determining Region Y Protein
- DNA
|
Topics |
- Biomarkers
(blood)
- Chromosome Disorders
(blood, diagnosis, genetics)
- DNA
(blood)
- Female
- Fetal Blood
(chemistry)
- Fetal Diseases
(blood, diagnosis, genetics)
- Fetus
(chemistry)
- Humans
- Male
- Maternal-Fetal Exchange
- Polymerase Chain Reaction
(methods)
- Pregnancy
- Pregnancy Trimester, First
(blood)
- Prenatal Diagnosis
(methods)
- Prognosis
- Prospective Studies
- Sex-Determining Region Y Protein
(blood, genetics)
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