Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans.

Abstract

Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h(2)=0.50+/-0.06, P<10(-6)). Multipoint linkage analysis using a approximately 10-cM microsatellite map revealed a region on Chromosome 19p near marker D19S586 showing strong evidence of linkage for sICAM-1 (empirically adjusted univariate-equivalent LOD=4.95), coincident with the structural gene ICAM1. This region has been identified previously as a QTL for inflammatory, autoimmune, and metabolic syndrome traits. There is significant evidence (P=0.0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait.

• Authors: Jack W Kent Jr, Michael C Mahaney, Anthony G Comuzzie, Harald H H Göring, Laura Almasy, Thomas D Dyer, Shelley A Cole, Jean W MacCluer, John Blangero
• Journal: Atherosclerosis (Atherosclerosis) Vol. 195 Issue 2 Pg. 367-73 (Dec 2007) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 17112530 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Intercellular Adhesion Molecule-1

Topics

• Adult
• Bayes Theorem
• Chromosomes, Human, Pair 19 (genetics)
• Cohort Studies
• Female
• Humans
• Inflammation
• Intercellular Adhesion Molecule-1 (genetics)
• Male
• Mexican Americans (genetics)
• Middle Aged
• Quantitative Trait Loci (genetics)