Antibodies to complement receptor 3 treat established inflammation in murine models of colitis and a novel model of psoriasiform dermatitis.

Abstract	Prior studies indicated the ability of Abs to complement receptor 3 (CR3, CD11b/CD18) to suppress the production of IL-12 from immune cells. Therefore, we tested the ability of an anti-CR3 Ab (clone M1/70) to treat established IL-12-dependent Th1-mediated inflammation in murine models. Systemic administration of anti-CR3 significantly ameliorated established intestinal inflammation following the intrarectal administration of trinitrobenzene sulfonic acid (TNBS-colitis), as well as colitis and skin inflammation in C57BL/10 RAG-2(-/-) mice reconstituted with CD4+CD45RBhigh T cells. The hyperproliferative skin inflammation in this novel murine model demonstrated many characteristics of human psoriasis, and was prevented by the adoptive transfer of CD45RBlow T cells. In vitro and in vivo studies suggest that anti-CR3 treatment may act, at least in part, by directly inhibiting IL-12 production by APCs. Administration of anti-CR3 may be a useful therapeutic approach to consider for the treatment of inflammatory bowel disease and psoriasis in humans.
Authors	Francisco Leon, Nikhat Contractor, Ivan Fuss, Thomas Marth, Edward Lahey, Shoko Iwaki, Andrea la Sala, Victoria Hoffmann, Warren Strober, Brian L Kelsall
Journal	Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 177 Issue 10 Pg. 6974-82 (Nov 15 2006) ISSN: 0022-1767 [Print] United States
PMID	17082612 (Publication Type: Journal Article)
Chemical References	Antibodies Inflammation Mediators Macrophage-1 Antigen Trinitrobenzenesulfonic Acid
Topics	Adoptive Transfer Animals Antibodies (administration & dosage, therapeutic use) CD4-Positive T-Lymphocytes (transplantation) Cells, Cultured Colitis (chemically induced, immunology, therapy) Dermatitis (immunology, pathology, therapy) Disease Models, Animal Female Inflammation Mediators (administration & dosage, therapeutic use) Injections, Intravenous Macrophage-1 Antigen (immunology) Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Psoriasis (immunology, pathology, therapy) Trinitrobenzenesulfonic Acid (toxicity)

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