Gallbladder carcinoma associated with pancreatobiliary reflux.

Abstract

AIM:

To detect the patients with and without pancreaticobiliary maljunction who had pancreatobiliary reflux with extremely high biliary amylase levels.

METHODS:

Ninety-six patients, who had diffuse thickness (>3 mm) of the gallbladder wall and were suspected of having a pancreaticobiliary maljunction on ultrasonography, were prospectively subjected to endoscopic retrograde cholangiopancreatography, and bile in the common bile duct was sampled. Among them, patients, who had extremely high biliary amylase levels (>10000 IU/L), underwent cholecystectomy, and the clinicopathological findings of those patients with and without pancreaticobiliary maljunction were examined.

RESULTS:

Seventeen patients had biliary amylase levels in the common bile duct above 10000 IU/L, including 11 with pancreaticobiliary maljunction and 6 without pancreaticobiliary maljunction. The occurrence of gallbladder carcinoma was 45.5% (5/11) in patients with pancreaticobiliary maljunction, and 50% (3/6) in those without pancreaticobiliary maljunction.

CONCLUSION:

Pancreatobiliary reflux with extremely high biliary amylase levels and associated gallbladder carcinoma could be identified in patients with and without pancreaticobiliary maljunction, and those patients might be detected by ultrasonography and bile sampling.

• Authors: Jin Kan Sai, Masafumi Suyama, Yoshihiro Kubokawa, Bunsei Nobukawa
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 12 Issue 40 Pg. 6527-30 (Oct 28 2006) ISSN: 1007-9327 [Print] United States
• PMID: 17072985 (Publication Type: Journal Article)

Chemical References

• Amylases

Topics

• Adult
• Aged
• Amylases (analysis)
• Bile Ducts (diagnostic imaging, pathology)
• Bile Reflux (etiology, pathology)
• Carcinoma (complications, pathology)
• Cholangiopancreatography, Endoscopic Retrograde
• Female
• Gallbladder Neoplasms (complications, pathology)
• Humans
• Male
• Middle Aged
• Pancreas (diagnostic imaging, pathology)
• Prospective Studies
• Ultrasonography