Polymorphism of gp15/400 allergen gene of Wuchereria bancrofti from different regions of India endemic for lymphatic filariasis.

Abstract	Nematode polyprotein allergens (NPA) are lipid-binding/transport molecules that elicit elevated levels of IgE response in the infected host, leading to Th2 type of immune response. They also transport arachidonic acid and metabolites that is known to be the action of antifilarial drug, diethylcarbamazine, and hence are of great significance to the control of lymphatic filariasis. We investigated the polymorphism of gp15/400 polyprotein of 35 isolates of lymphatic filarial parasite Wuchereria bancrofti collected from different geographic locations of India. The repeat subunit of the gene was found to be highly conserved in all the isolates with only two nucleotide synonymous changes at positions 369 (A-G) and 375 (C-T). As this molecule is highly conserved and has multifarious roles in the survival and pathogenesis of the parasite, it has good potential as a target for drug, immunodulation tools and immunotherapy development.
Authors	S L Hoti, R Thangadurai, K P Patra, P K Das
Journal	Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (Infect Genet Evol) Vol. 7 Issue 2 Pg. 213-8 (Mar 2007) ISSN: 1567-1348 [Print] Netherlands
PMID	17056300 (Publication Type: Duplicate Publication, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Allergens Antibodies, Helminth Antigens, Helminth GP15-400 protein, Wuchereria bancrofti Helminth Proteins Membrane Glycoproteins
Topics	Allergens (chemistry, genetics) Amino Acid Sequence Animals Antibodies, Helminth Antigens, Helminth (chemistry, genetics) Base Sequence Elephantiasis, Filarial (epidemiology, immunology, parasitology) Endemic Diseases Genes, Helminth Helminth Proteins (chemistry, genetics) India (epidemiology) Membrane Glycoproteins (chemistry, genetics) Molecular Sequence Data Phylogeny Polymorphism, Genetic Sequence Alignment Wuchereria bancrofti (genetics, immunology)

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