Diagnosis of Paracoccidioidomycosis by detection of antigen and antibody in bronchoalveolar lavage fluids.

Abstract

Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides brasiliensis and is believed to be the leading cause of fungal pulmonary infection. In this study, we used an inhibition enzyme-linked immunosorbent assay to diagnose pulmonary PCM based on the detection of 43-kDa and 70-kDa molecules in bronchoalveolar lavage fluids. The results were compared with results obtained by classical methods for antibody detection.

• Authors: Silvia Helena Marques-da-Silva, Arnaldo Lopes Colombo, Maria Heloisa Souza Lima Blotta, Flávio Queiroz-Telles, Alípio Barbosa Balthazar, José Daniel Lopes, Zoilo Pires de Camargo
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 13 Issue 12 Pg. 1363-6 (Dec 2006) ISSN: 1556-6811 [Print] United States
• PMID: 17035512 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 43 kDa protein, Paracoccidioides
• Antibodies, Fungal
• Antigens, Fungal
• Fungal Proteins
• Glycoproteins

Topics

• Antibodies, Fungal (analysis)
• Antigens, Fungal (analysis)
• Bronchoalveolar Lavage Fluid (immunology, microbiology)
• Fungal Proteins (analysis)
• Glycoproteins (analysis)
• Humans
• Lung Diseases, Fungal (immunology, microbiology)
• Paracoccidioides (immunology)
• Paracoccidioidomycosis (diagnosis, microbiology)