Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.

Abstract

OBJECTIVE:

To explore the potential role of the endogenous peptide YY (PYY) in the long-term regulation of body weight and energy homeostasis.

RESEARCH METHODS AND PROCEDURES:

Fasting and postprandial plasma PYY concentrations were measured after an overnight fast and 30 to 180 minutes after a standardized meal in 29 (21 men/8 women) non-diabetic subjects, 16 of whom had a follow-up visit 10.8 +/- 1.4 months later. Ratings of hunger and satiety were collected using visual analog scales. Resting metabolic rate (RMR) (15-hour RMR) and respiratory quotient (RQ) were assessed using a respiratory chamber.

RESULTS:

Fasting PYY concentrations were negatively correlated with various markers of adiposity and negatively associated with 15-hour RMR (r = -0.46, p = 0.01). Postprandial changes in PYY (area under the curve) were positively associated with postprandial changes in ratings of satiety (r = 0.47, p = 0.01). The maximal PYY concentrations achieved after the meal (peak PYY) were negatively associated with 24-hour RQ (r = -0.41, p = 0.03). Prospectively, the peak PYY concentrations were negatively associated with changes in body weight (r = -0.58, p = 0.01).

DISCUSSION:

Our data indicate that the endogenous PYY may be involved in the long-term regulation of body weight. It seems that this long-term effect was not exclusively driven by the modulation of food intake but also by the control of energy expenditure and lipid metabolism.

• Authors: Yan Guo, Lijun Ma, Pablo J Enriori, Juraj Koska, Paul W Franks, Thomas Brookshire, Michael A Cowley, Arline D Salbe, Angelo Delparigi, P Antonio Tataranni
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 14 Issue 9 Pg. 1562-70 (Sep 2006) ISSN: 1930-7381 [Print] United States
• PMID: 17030967 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Blood Glucose
• Insulin
• Peptide YY

Topics

• Adolescent
• Adult
• Area Under Curve
• Basal Metabolism (physiology)
• Blood Glucose (metabolism)
• Body Weight (physiology)
• Energy Metabolism (physiology)
• Fasting (blood)
• Female
• Glucose Tolerance Test
• Humans
• Hunger (physiology)
• Insulin (blood)
• Lipid Metabolism
• Male
• Middle Aged
• Obesity (metabolism)
• Oxygen Consumption (physiology)
• Peptide YY (physiology)
• Postprandial Period
• Satiety Response (physiology)