A novel treatment for ischemic intracranial hypertension in cats.

Abstract

There is no accepted efficacious treatment for ischemic cerebral edema. We show in a cat model of focal cerebral ischemia that infarct volume can be reduced (p less than 0.05) by ventriculocisternal perfusion with an oxygenated fluorochemical emulsion (bis-perfluorobutylethylene). An accompanying effect of such ventriculocisternal perfusion is a reduction in intracranial pressure. At 18 hours following the start of the perfusion, there was a significant (p less than 0.05) difference in intracranial pressure between nonperfused controls (mean 11.4 [range 2.3-23.0] torr, n = 6) and cats perfused with an oxygenated nutrient solution not containing fluorochemical (mean 11.3 [range 3.0-29.0] torr, n = 8) or animals perfused with the oxygenated fluorochemical emulsion (mean 2.21 [range 0-3.5] torr, n = 7). Perfusion with this oxygenated fluorochemical emulsion warrants further study as a treatment for elevated intracranial pressure.

• Authors: R D Bell, G D Frazer, J L Osterholm, S W Duckett
• Journal: Stroke (Stroke) Vol. 22 Issue 1 Pg. 80-3 (Jan 1991) ISSN: 0039-2499 [Print] United States
• PMID: 1702909 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorocarbons
• Tetrazolium Salts
• triphenyltetrazolium
• bis(perfluorobutyl)ethene

Topics

• Animals
• Brain (pathology)
• Brain Ischemia (physiopathology)
• Cats
• Cerebral Infarction (pathology)
• Fluorocarbons (pharmacology)
• Intracranial Pressure
• Male
• Perfusion
• Staining and Labeling
• Tetrazolium Salts