Outbreak of toxic anterior segment syndrome associated with glutaraldehyde after cataract surgery.

Abstract

PURPOSE:

To present clinical findings of a cluster of cases of toxic anterior segment syndrome (TASS) after uneventful phacoemulsification cataract surgery.

SETTING:

Department of Ophthalmology, Akdeniz University, Antalya, Turkey.

METHODS:

Six eyes of 6 patients developed TASS after uneventful phacoemulsification cataract surgery with implantation of a 3-piece acrylic IOL performed by 2 ophthalmologists on the same day. Clinical findings included corneal edema, Descemet's membrane folds, anterior chamber reaction, fibrin formation, and irregular, dilated, and unreactive pupils.

RESULTS:

Glutaraldehyde 2% solution was used inadvertently by the operating room staff who cleaned and sterilized reusable ocular instruments before autoclaving. None of the affected corneas improved. Additional surgical procedures were required and included penetrating keratoplasty, trabeculectomy, and glaucoma tube implantation.

CONCLUSIONS:

Glutaraldehyde in concentrations generally used for cold sterilization is highly toxic to the corneal endothelium. The operating room staff involved in sterilizing instruments should be well educated about and careful to follow the protocols to properly clean and sterilize reusable ocular instruments.

• Authors: Mustafa Unal, Iclal Yücel, Yusuf Akar, Asli Oner, Meryem Altin
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 32 Issue 10 Pg. 1696-701 (Oct 2006) ISSN: 0886-3350 [Print] United States
• PMID: 17010870 (Publication Type: Case Reports, Journal Article)

Chemical References

• Disinfectants
• Fibrin
• Glutaral

Topics

• Aged
• Anterior Eye Segment (drug effects, metabolism, pathology)
• Corneal Edema (chemically induced, diagnosis, epidemiology, surgery)
• Descemet Membrane (drug effects, pathology)
• Disease Outbreaks
• Disinfectants (adverse effects)
• Drug Hypersensitivity (diagnosis, etiology)
• Female
• Fibrin (metabolism)
• Glutaral (adverse effects)
• Humans
• Lens Implantation, Intraocular
• Male
• Middle Aged
• Phacoemulsification
• Pupil Disorders (chemically induced, epidemiology)
• Syndrome
• Turkey (epidemiology)