Abstract | OBJECTIVE: BACKGROUND: METHODS: A total of 109 patients with end-stage lung disease awaiting lung transplantation underwent symptomatic assessment, esophageal manometry, and esophageal pH monitoring (using a probe with 2 sensors located 5 and 20 cm above the lower esophageal sphincter). RESULTS: Reflux symptoms were not predictive of the presence of reflux (sensitivity, 67%; specificity, 26%). Esophageal manometry showed a high prevalence of a hypotensive lower esophageal sphincter (55%) and impaired esophageal peristalsis (47%) among patients with reflux. Distal reflux was present in 68% of patients and proximal reflux was present in 37% of patients. CONCLUSIONS: These data show that in patients with end-stage lung disease: 1) symptoms were insensitive and nonspecific for diagnosing reflux; 2) esophageal motility was frequently abnormal; 3) 68% of patients had GERD; 4) in 50% of the patients with GERD, acid refluxed into the proximal esophagus. We conclude that patients with end-stage lung disease should be screened with pH monitoring for GERD.
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Authors | Matthew P Sweet, Fernando A M Herbella, Lorriana Leard, Charles Hoopes, Jeffrey Golden, Steven Hays, Marco G Patti |
Journal | Annals of surgery
(Ann Surg)
Vol. 244
Issue 4
Pg. 491-7
(Oct 2006)
ISSN: 0003-4932 [Print] United States |
PMID | 16998357
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Female
- Gastroesophageal Reflux
(epidemiology, etiology)
- Humans
- Lung Diseases
(complications, physiopathology)
- Lung Transplantation
- Male
- Middle Aged
- Prevalence
- Waiting Lists
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