Impact of antiretroviral treatment-related toxicities on hospital admissions in HIV-infected patients.

Abstract

While classical opportunistic infections have decreased as the main cause of hospital admission of HIV-infected patients, other conditions including drug-related toxicities seem to have increased. We assessed the proportion of patients with hospital admission due to antiretroviral (ARV)-related toxicities over the last 7 years at a single HIV/AIDS reference institution located in Madrid. A total of 1981 consecutive hospital admissions in 1581 different HIV-infected patients were analyzed. Nearly half of them (45%) were on ARV therapy. Overall, ARV-related toxicities were the main or secondary reason for hospital admission in 141 patients (7%). Liver toxicity was the most frequent complication (n = 42; 30%), of which one-third were associated with NVP use and 80% occurred in subjects with underlying chronic hepatitis C virus (HCV) infection. Other main ARV-related toxicities were bone marrow toxicity due to zidovudine (17%), pancreatitis (13%), and indinavirassociated nephrolithiasis (6%). Eight patients presented with symptomatic hyperlactatemia, two of them with lactic acidosis. All subjects with ARV-related toxicities had a favorable outcome, except one with prior HCVrelated end-stage liver disease, who died after experiencing hepatic decompensation following initiation of a protease inhibitor-based regimen.

• Authors: María José Núñez, Luz Martín-Carbonero, Victoria Moreno, Eulalia Valencia, Javier Garcia-Samaniego, Juan González Del Castillo, Pablo Barreiro, Juan González-Lahoz, Vincent Soriano
• Journal: AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 22 Issue 9 Pg. 825-9 (Sep 2006) ISSN: 0889-2229 [Print] United States
• PMID: 16989605 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Retroviral Agents

Topics

• Acquired Immunodeficiency Syndrome (drug therapy)
• Adult
• Anti-Retroviral Agents (adverse effects)
• Antiretroviral Therapy, Highly Active (adverse effects)
• Drug Therapy, Combination
• Female
• Hepatitis C (complications)
• Hospitalization (trends)
• Humans
• Male
• Regression Analysis
• Retrospective Studies
• Spain