Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study.

Abstract

We conducted a case-control study of medulloblastoma/primitive neuroectodermal tumors of brain (PNET) to pursue findings related to vitamin and mineral supplements, micronutrients, and cured meat consumption during gestation. Mothers of 315 cases ages <6 years at diagnosis in 1991 to 1997 identified from the United States and Canada through the Children's Oncology Group and mothers of 315 controls selected by random-digit dialing were interviewed. In the periconception period of the index pregnancy, case mothers were less likely than control mothers to report use of multivitamins [adjusted odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.4-1.0; P = 0.08] and to be in the highest quartile of iron and folate intake from food and supplements combined (adjusted OR for iron, 0.5; 95% CI, 0.3-0.9; P(trend) = 0.008; adjusted OR for folate, 0.5; 95% CI, 0.3-0.9; P(trend) = 0.007). Case and control mothers had similar intakes of cured meats, although case mothers were more likely to have the combination of high cured meat and low vitamin C intake (OR, 1.5; 95% CI, 1.0-2.3; P = 0.08). The results of the study add to the evidence of a protective role for multivitamins, suggest a possible role for micronutrients early in pregnancy, and generally do not support an association between cured meats and medulloblastoma/PNET.

• Authors: Greta R Bunin, Paul R Gallagher, Lucy B Rorke-Adams, Leslie L Robison, Avital Cnaan
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 15 Issue 9 Pg. 1660-7 (Sep 2006) ISSN: 1055-9965 [Print] United States
• PMID: 16985028 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Micronutrients
• Vitamins
• Folic Acid
• Iron

Topics

• Case-Control Studies
• Cerebellar Neoplasms (etiology, prevention & control)
• Child
• Dietary Supplements
• Female
• Folic Acid (administration & dosage)
• Humans
• Iron (administration & dosage)
• Meat Products (adverse effects)
• Medulloblastoma (etiology, prevention & control)
• Micronutrients (administration & dosage)
• Odds Ratio
• Pregnancy
• Vitamins (administration & dosage)