Use of biologics in rheumatoid arthritis: where are we going?

Abstract

PURPOSE:

The pharmacology, efficacy, safety, and costs of biologic agents that are approved by the Food and Drug Administration or are under review for the management of rheumatoid arthritis (RA) are discussed. Biologic therapies that are currently under investigation in early- and late-phase clinical trials are summarized at the end of this report.

SUMMARY:

The use of biologic agents for the treatment of RA has significantly improved the management of this disease. Experimental and clinical studies have shown that these agents ameliorate the signs and symptoms of RA, slow radiographic progression of disease, and improve physical function and quality of life. Data also support that early initiation of therapy with these agents improves long-term outcomes. However, biologic agents are associated with adverse effects that health care providers need to recognize and manage.

CONCLUSION:

Biologic agents have revolutionized the treatment of RA by reducing the signs and symptoms of RA, slowing radiographic progression of joint destruction, and improving physical function and quality of life in affected patients.

• Authors: Frank Pucino Jr, Phyllis Tish Harbus, Raphaela Goldbach-Mansky
• Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists (Am J Health Syst Pharm) Vol. 63 Issue 18 Suppl 4 Pg. S19-41 (Sep 15 2006) ISSN: 1079-2082 [Print] England
• PMID: 16960244 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antibodies, Monoclonal, Murine-Derived
• Antirheumatic Agents
• Biological Products
• Immunoconjugates
• Interleukin 1 Receptor Antagonist Protein
• Tumor Necrosis Factor Inhibitors
• Rituximab
• Abatacept
• tocilizumab

Topics

• Abatacept
• Antibodies, Monoclonal (adverse effects, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antibodies, Monoclonal, Murine-Derived
• Antirheumatic Agents (therapeutic use)
• Arthritis, Rheumatoid (drug therapy, economics)
• Biological Products (adverse effects, economics, therapeutic use)
• Clinical Trials as Topic
• Disease Progression
• Humans
• Immunoconjugates (adverse effects, therapeutic use)
• Interleukin 1 Receptor Antagonist Protein (adverse effects, economics, therapeutic use)
• Quality of Life
• Rituximab
• Tumor Necrosis Factor Inhibitors