Fe(III) improves antioxidant and cytoprotecting activities of mangiferin.

Abstract

Iron-induced oxidative stress has been implicated in several pathological processes. In the present work we provide evidence for the formation of a mangiferin:Fe(III) complex (2:1), shown by means of either iron-induced changes in the UV/visible spectrum of mangiferin or by reduction of the anodic current peak in the voltammogram of that compound; we demonstrate, in addition, that the ferric complex is more effective than mangiferin itself in scavenging superoxide radicals generated by pyrogallol autoxidation, as well as in protecting hepatocytes from reactive oxygen species mediated hypoxia/reoxygenation injury. Moreover, we found that the mangiferin:Fe(III) complex reacts more readily with horseradish peroxidase/H(2)O(2) than does mangiferin by itself. We postulate that mangiferin could afford protection against iron/reactive oxygen species-mediated pathological processes by means of both iron chelating and iron-stimulated superoxide radical scavenging activity.

• Authors: Gilberto L Pardo-Andreu, Carlos Sánchez-Baldoquín, Rizette Avila-González, René Delgado, Zeki Naal, Carlos Curti
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 547 Issue 1-3 Pg. 31-6 (Oct 10 2006) ISSN: 0014-2999 [Print] Netherlands
• PMID: 16945365 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Ferric Compounds
• Free Radical Scavengers
• Reactive Oxygen Species
• Xanthones
• Superoxides
• mangiferin
• Oxygen

Topics

• Animals
• Antioxidants (pharmacology)
• Cell Hypoxia
• Cell Survival (drug effects)
• Cells, Cultured
• Drug Synergism
• Electrochemistry
• Ferric Compounds (chemistry, pharmacology)
• Free Radical Scavengers (chemistry, pharmacology)
• Hepatocytes (drug effects, metabolism, pathology)
• Male
• Molecular Structure
• Oxygen (pharmacology)
• Rats
• Rats, Wistar
• Reactive Oxygen Species (metabolism)
• Spectrophotometry, Ultraviolet
• Superoxides (antagonists & inhibitors, metabolism)
• Xanthones (chemistry, pharmacology)