[Studies on the association between beta 2-glycoprotein I and hepatotropism of hepatitis B virus].

Abstract

OBJECTIVE:

To further study the binding character of hepatitis B surface antigen (HBsAg) and beta 2-glycoprotein I (beta2GP I) and to explore whether beta2GP I plays an important role in the hepatotropism of hepatitis B virus.

METHODS:

Using Western blot technique, we observed the binding character of the HBsAg with reduced and non-reduced beta2GP I.

RESULTS:

rHBsAgs with reduced and non-reduced beta2GP I showed identical binding activity.

CONCLUSIONS:

The binding activity of HBsAg is dependent on tandem residues, but not on conformational structures of beta2GP I. There is a specific binding between HBV and beta2GP I, which may play an important role in HBV infection and is one of the reasons of hepatotropism of HBV.

• Authors: Yan-hang Gao, Pu-jun Gao, Dan Wang, Yang Shi, Tong-yu Tang, Yun-feng Piao, Han-yi Yang
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 14 Issue 8 Pg. 569-71 (Aug 2006) ISSN: 1007-3418 [Print] China
• PMID: 16938165 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hepatitis B Surface Antigens
• Viral Envelope Proteins
• beta 2-Glycoprotein I

Topics

• Hepatitis B (virology)
• Hepatitis B Surface Antigens (metabolism)
• Hepatitis B virus (pathogenicity)
• Humans
• Viral Envelope Proteins (blood)
• beta 2-Glycoprotein I (blood)