Abstract | BACKGROUND: The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs ( Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of intracellular sorting and trafficking functions. These proteins are highly expressed in the brain. SorLA has been shown to be down regulated in Alzheimer's disease brains, interact with ApoE, and modulate Abeta production. Sortilin has been shown to be part of proNGF mediated death signaling that results from a complex of Sortilin, p75NTR and proNGF. We have investigated and provide evidence for gamma-secretase cleavage of this family of proteins. RESULTS: CONCLUSION: These data indicate that the alpha- and gamma-secretase cleavages of the mammalian Vps10p sorting receptors occur in a fashion analogous to other known gamma-secretase substrates, and could possibly regulate the biological functions of these proteins.
|
Authors | Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah, Todd E Golde |
Journal | Molecular neurodegeneration
(Mol Neurodegener)
Vol. 1
Pg. 3
(Jun 12 2006)
ISSN: 1750-1326 [Electronic] England |
PMID | 16930450
(Publication Type: Journal Article)
|