Abstract | BACKGROUND: Concurrent with the rise in obesity, nonalcoholic fatty liver disease is recognized as the leading cause of serum aminotransferase elevations in obese youth. Nevertheless, the complete metabolic phenotype associated with abnormalities in biomarkers of liver injury and intrahepatic fat accumulation remains to be established. METHODS: FINDINGS: Elevated ALT (> 35 U/liter) was found in 14% of adolescents, with a predominance of male gender and white/Hispanic race/ethnicity. After adjusting for potential confounders, rising ALT was associated with reduced insulin sensitivity and glucose tolerance as well as rising free fatty acids and triglycerides. Worsening of glucose and lipid metabolism was already evident as ALT levels rose into the upper half of the normal range (18-35 U/liter). When hepatic fat fraction was assessed using fast magnetic resonance imaging, 32% of subjects had an increased hepatic fat fraction, which was associated with decreased insulin sensitivity and adiponectin, and increased triglycerides, visceral fat, and deep to superficial sc fat ratio. The prevalence of the metabolic syndrome was significantly greater in those with fatty liver. INTERPRETATION:
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Authors | Tania S Burgert, Sara E Taksali, James Dziura, T Robin Goodman, Catherine W Yeckel, Xenophon Papademetris, R Todd Constable, Ram Weiss, William V Tamborlane, Mary Savoye, Aisha A Seyal, Sonia Caprio |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 91
Issue 11
Pg. 4287-94
(Nov 2006)
ISSN: 0021-972X [Print] United States |
PMID | 16912127
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Biomarkers
- Alanine Transaminase
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Topics |
- Adiponectin
(blood)
- Adipose Tissue
(metabolism)
- Adolescent
- Adult
- Alanine Transaminase
(blood)
- Biomarkers
- Body Mass Index
- Child
- Cohort Studies
- Fatty Liver
(etiology)
- Female
- Humans
- Insulin Resistance
- Intra-Abdominal Fat
(anatomy & histology)
- Liver
(enzymology, metabolism)
- Male
- Obesity
(blood, complications, ethnology)
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