Prophylactic aspirin therapy does not increase faecal calprotectin concentrations.

Abstract

OBJECTIVE:

Non-steroidal anti-inflammatory drugs (NSAID) can induce enteropathy. Aspirin ingestion is associated with a lower small-intestinal inflammation than other NSAID. Faecal calprotectin concentrations have recently been proposed as a simple non-invasive test to identify NSAID enteropathy. The aim of our pilot study was to evaluate calprotectin concentrations in patients on treatment with low-dose aspirin.

METHODS:

Twenty-two patients on prophylactic treatment with aspirin were recruited. Twenty-five healthy volunteers were enrolled as a control group. Faecal calprotectin concentrations were determined by enzyme-linked immunosorbent assay. Statistical analysis was performed by t-test for unpaired data.

RESULTS:

The mean faecal calprotectin concentration in patients (57.95+/-44.28 microg/g) did not show significant differences compared with controls (45.76+/-26.45 microg/g; P=0.251).

CONCLUSIONS:

We found that low-dose aspirin does not induce an increase in faecal calprotectin increase.

• Authors: Massimo Montalto, Valentina Curigliano, Luca Santoro, Mariaelena Lombardi, Marcello Covino, Giovanni Cammarota, Sara Dalvai, Ferruccio D'Onofrio, Antonio Gasbarrini, Giovanni Gasbarrini
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 18 Issue 9 Pg. 965-7 (Sep 2006) ISSN: 0954-691X [Print] England
• PMID: 16894309 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Biomarkers
• Leukocyte L1 Antigen Complex
• Aspirin

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Aspirin (adverse effects)
• Biomarkers (analysis)
• Carotid Artery Diseases (drug therapy)
• Case-Control Studies
• Enteritis (chemically induced)
• Feces (chemistry)
• Female
• Humans
• Leukocyte L1 Antigen Complex (analysis)
• Male
• Middle Aged
• Pilot Projects