Combined intoxication with methylone and 5-MeO-MIPT.

Abstract

Although preclinical studies suggest that methylone (2-methylamino-1-[3,4-methylenedioxyphenyl]propan-1-one) and 5-MeO-MIPT (5-methoxy-N-methyl,N-isopropyl tryptamine) may have psychostimulant properties, the scientific reports about the clinical effects of these agents are scant. We describe a 27-year-old male patient with substance intoxication after a single ingestion of the mixture of methylone and 5-MeO-MIPT. Though he bought the drug as pure methylone powder via an internet order, our chemical analyses indicated that the drug was composed of about 60% methylone (120 mg) and 38% 5-MeO-MIPT (76 mg). This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs.

• Authors: Eiji Shimizu, Hiroyuki Watanabe, Takashi Kojima, Hiroko Hagiwara, Mihisa Fujisaki, Ryosuke Miyatake, Kenji Hashimoto, Masaomi Iyo
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 31 Issue 1 Pg. 288-91 (Jan 30 2007) ISSN: 0278-5846 [Print] England
• PMID: 16876302 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tryptamines
• Methamphetamine
• 5-methoxy-N-methyl,N-isopropyl tryptamine
• methylone

Topics

• Adult
• Akathisia, Drug-Induced (psychology)
• Chromatography, High Pressure Liquid
• Gas Chromatography-Mass Spectrometry
• Humans
• Male
• Methamphetamine (analogs & derivatives, analysis, poisoning)
• Psychoses, Substance-Induced (psychology)
• Substance-Related Disorders (psychology)
• Tryptamines (analysis, poisoning)