Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism.

Abstract

We have studied the serology of 6 patients with palindromic rheumatism. None of the patients fulfilled the classification criteria for rheumatoid arthritis at the entry; however, 4 out of the 6 patients were seropositive for IgM rheumatoid factor (IgM-RF) at entry. Sequential serological study was performed in 4 patients; IgM-RF changed from seronegative to seropositive in one patient, and the titer increased in another patient. Anti-cyclic citrullinated peptide antibody (anti-CCP Ab) at the entry was detected in only one of the 6 patients; that patient later developed RA. Although follow-up is necessary, the present study may suggest the importance of serological examination, especially anti-CCP Ab, in patients with palindromic rheumatism.

• Authors: Mami Tamai, Atsushi Kawakami, Nozomi Iwanaga, Keita Fujikawa, Fumiko Tanaka, Toshiyuki Aramaki, Yasumori Izumi, Kouichiro Aratake, Kazuhiko Arima, Makoto Kamachi, Hideki Nakamura, Mingguo Huang, Hiroaki Ida, Tomoki Origuchi, Katsumi Eguchi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 45 Issue 12 Pg. 795-7 ( 2006) ISSN: 1349-7235 [Electronic] Japan
• PMID: 16847371 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin M
• Peptides, Cyclic
• cyclic citrullinated peptide
• Rheumatoid Factor

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (immunology)
• Female
• Humans
• Immunoglobulin M (blood)
• Male
• Middle Aged
• Peptides, Cyclic (blood, immunology)
• Rheumatoid Factor (blood, immunology)