Probiotics. Antistaphylococcal and antifibrinolytic activities of omega-amino-and omega-guanidinoalkanisulfonic acids.

Abstract

A series of omega-aminoalkanesulfonic acids (1-5) and omega-guanidinoalkanesulfonic acids (6-9) has been tested for antistaphylococcal and antifibrinolytic activities. Most of the omega-aminoalkanesulfonic acids and 6 produced better protection against Staphylococcus aureus infections in mice than gamma-aminobutyryl-L-histidine. Compound 4 was the best antistaphylococcal agent among the omega-aminoalkanesulfonic acids and compound 6 among the omega-guanidinoalkanesulfonic acids. Most of the omega-aminoalkanesulfonic acids have antifibrinolytic activity, while none of the omega-guanidinoalkanesulfonic acids has significant antifibrinolytic activity. Compound 4 possessed the highest antifibrinolytic activity which was equal to or greater than that of epsilon-aminohexanoic acid.

• Authors: A Fujii, E S Cook
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 18 Issue 5 Pg. 502-5 (May 1975) ISSN: 0022-2623 [Print] United States
• PMID: 168383 (Publication Type: Journal Article)

Chemical References

• Alkanesulfonates
• Amines
• Anti-Infective Agents
• Antifibrinolytic Agents
• Guanidines

Topics

• Alkanesulfonates (chemical synthesis, pharmacology, therapeutic use)
• Amines (chemical synthesis, pharmacology, therapeutic use)
• Animals
• Anti-Infective Agents (chemical synthesis, therapeutic use)
• Antifibrinolytic Agents (chemical synthesis, pharmacology)
• Blood Coagulation Tests
• Chromatography, Thin Layer
• Fibrinolysis (drug effects)
• Guanidines (chemical synthesis, pharmacology)
• Mice
• Staphylococcal Infections (drug therapy)
• Time Factors