Abstract | PURPOSE: METHODS: Male Sprague-Dawley rats (4-8/group) were treated with two haloperidol decanoate intramuscular shots one week apart (21 mg/kg) or twice daily olanzapine intraperitoneal injections at low dose (1 mg/kg/day) or high dose (6 mg/kg/day) for 7 days prior to ICV administration of ouabain. Open field locomotion was quantified at baseline and after ouabain administration. RESULTS:
Ouabain caused a significant increase in open field locomotion (253.7+/-SEM 55.12 vs control 53.1+/-12.13 squares traversed in 30 min in the olanzapine experiments, P<0.05; and 236.5+/-41.42 vs 129.3+/-38.23, P<0.05 in the haloperidol experiments). Olanzapine alone at low dose (102.2+/-37.7) or high dose (151.2+/-49.2) did not alter open field activity. Low dose olanzapine (176.6+/-73.27) but not high dose (307.5+/-167.32) caused a modest reduction of the ouabain effect. Haloperidol alone significantly reduced motoric activity compared to control (55.6+/-18.0, P<0.05), and prevented ouabain-induced hyperactivity (60.3+/-33.1, P<0.05). CONCLUSION:
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Authors | Rif S El-Mallakh, Sarah Decker, Matthew Morris, Xiao-Ping Li, Mary O'Malley Huff, M Adnan El-Masri, Robert S Levy |
Journal | Progress in neuro-psychopharmacology & biological psychiatry
(Prog Neuropsychopharmacol Biol Psychiatry)
Vol. 30
Issue 7
Pg. 1261-4
(Sep 30 2006)
ISSN: 0278-5846 [Print] England |
PMID | 16815616
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Enzyme Inhibitors
- Benzodiazepines
- Ouabain
- Haloperidol
- Olanzapine
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Topics |
- Analysis of Variance
- Animals
- Antipsychotic Agents
(therapeutic use)
- Behavior, Animal
(drug effects)
- Benzodiazepines
(therapeutic use)
- Bipolar Disorder
(drug therapy)
- Disease Models, Animal
- Drug Evaluation
- Drug Interactions
- Enzyme Inhibitors
(therapeutic use)
- Exploratory Behavior
(drug effects)
- Haloperidol
(therapeutic use)
- Male
- Olanzapine
- Ouabain
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
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