Abstract | BACKGROUND: METHODS: Fifteen secondary amyloid A amyloidosis patients (4 men, 11 women; age, 23-70 years) were treated with DMSO between 1995 and 2003. DMSO was administered orally in all patients at a dose of 3-20 g/day. The clinical symptoms together with the renal and gastrointestinal functions were evaluated before and after treatment. RESULTS: Among the 15 patients, amyloid A amyloidosis was a complication of rheumatoid arthritis (RA) in 10, of Crohn's disease in 4, and of Adult Still's disease in 1. Nine cases mainly involved the kidney, with renal dysfunction and proteinuria, five mainly involved the gastrointestinal tract, with protein-losing gastroenteropathy and intractable diarrhea, and one involved both gastrointestinal and renal amyloidosis. DMSO treatment was successful in 10 (66.7%) of the 15 patients (RA, 6/10; Crohn's disease, 4/4; Adult Still's disease, 0/1). Eight weeks of DMSO administration improved the renal function and proteinuria in five out of ten renal amyloidosis patients, but had no effect on those patients with severe and/or advanced renal dysfunction. With regard to gastrointestinal amyloidosis, gastrointestinal symptoms, including diarrhea and protein-losing gastroenteropathy, were improved in six patients. No serious side effects were encountered with the DMSO treatment. CONCLUSIONS:
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Authors | Sadahiro Amemori, Ryuichi Iwakiri, Hiroyoshi Endo, Akifumi Ootani, Shinichi Ogata, Takahiro Noda, Seiji Tsunada, Hiroyuki Sakata, Hisashi Matsunaga, Masanobu Mizuguchi, Yuji Ikeda, Kazuma Fujimoto |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 41
Issue 5
Pg. 444-9
(May 2006)
ISSN: 0944-1174 [Print] Japan |
PMID | 16799886
(Publication Type: Journal Article)
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Chemical References |
- Serum Amyloid A Protein
- Dimethyl Sulfoxide
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Topics |
- Administration, Oral
- Adult
- Aged
- Amyloidosis
(drug therapy)
- Diarrhea
(prevention & control)
- Dimethyl Sulfoxide
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Medical Records
- Middle Aged
- Retrospective Studies
- Serum Amyloid A Protein
- Stomach Diseases
(prevention & control)
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