[Evaluation of the effect of fertility-saving surgery on young patients with malignant ovarian tumors].

Abstract

OBJECTIVE:

To evaluate the impact of fertility-saving surgery and adjuvant chemotherapy on survival and fertility of young patients with ovarian malignant tumors.

METHODS:

A retrospective analysis was done on 38 patients with ovarian malignant germ cell tumors, 22 patients with malignant epithelial tumors and 4 patients with sexual cord mesenchymal tumors receiving conservative treatments. Outcomes such as menstruation and reproduction ability were assessed.

RESULTS:

Fifty-nine among 64 patients have been alive up to now (92%). The overall survival rate for ovarian epithelial malignancies, malignant germ cell tumors and sexual cord mesenchymal tumors were 95% (21/22), 89% (34/38) and 4/4, respectively. Fifteen patients received second operation and recurrence was found in 6 patients. Among the 59 surviving patients, 53 had normal menstruation. Thirteen patients among 20 patients who wanted to get pregnant had 15 pregnancies and 9 successful deliveries.

CONCLUSIONS:

The management of fertility-saving surgery on patients with ovarian malignant germ cell tumors, whatever the stagings are, is a safe option. For patients with ovarian epithelial carcinomas, fertility-saving surgery is only indicated for low-stage (stage I), high-grade (G1), and patients who hope to maintain fertility function eagerly. Cisplatinum-based combination chemotherapy is necessary. Standardized chemotherapy has no effect on fertility function.

• Authors: Ming-rong Xi, Min-min Hou, Ze-yi Cao, Chong-shu Zhang, Zhi-lan Peng, Hong-jing Wang, Ai Zheng
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 41 Issue 4 Pg. 233-6 (Apr 2006) ISSN: 0529-567X [Print] China
• PMID: 16759456 (Publication Type: Evaluation Study, Journal Article)

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Child
• Female
• Fertility
• Follow-Up Studies
• Germinoma (drug therapy, mortality, surgery)
• Humans
• Lymph Node Excision
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Ovarian Neoplasms (drug therapy, mortality, surgery)
• Ovariectomy (methods)
• Pregnancy
• Pregnancy Outcome
• Reproducibility of Results
• Retrospective Studies
• Survival Rate
• Treatment Outcome