Is grand multiparity associated with an increased risk of dysglycaemia?

Abstract

AIMS/HYPOTHESIS:

We sought to determine the risk of diabetes and IGT/IFG with grand multiparity.

SUBJECTS, MATERIALS AND METHODS:

Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]).

RESULTS:

After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status.

CONCLUSIONS/INTERPRETATION:

Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.

• Authors: D Simmons, J Shaw, A McKenzie, S Eaton, A J Cameron, P Zimmet
• Journal: Diabetologia (Diabetologia) Vol. 49 Issue 7 Pg. 1522-7 (Jul 2006) ISSN: 0012-186X [Print] Germany
• PMID: 16752170 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Contraceptive Agents, Female

Topics

• Adult
• Aged
• Aged, 80 and over
• Australia
• Blood Glucose (analysis)
• Case-Control Studies
• Contraceptive Agents, Female (adverse effects)
• Diabetes Mellitus (blood, etiology)
• Diabetes, Gestational (epidemiology)
• Female
• Glucose Intolerance (etiology)
• Glucose Tolerance Test
• Health Surveys
• Humans
• Hysterectomy (adverse effects)
• Middle Aged
• Parity
• Postmenopause (blood)
• Pregnancy
• Random Allocation
• Risk Factors
• Surveys and Questionnaires