Abstract |
The objective of this study was to assess the effect of six-monthly professional applications of chlorhexidine varnish on the prevention of dental caries in primary molars in Chinese preschool children. In a double-blinded, randomized, placebo-controlled clinical trial, 334 children aged 4-5 years were randomly divided into two groups. Children in the test group received six-monthly applications of a 40% chlorhexidine varnish, and the control children received a placebo varnish. Caries status of the children was assessed by two calibrated examiners at baseline and after 24 months, according to criteria recommended by the World Health Organization. The two-year mean caries increments in the test and the control group children were 1.0 and 1.6 decayed, missing, or filled molar surfaces (dmfs-molar), respectively, a 37.3% reduction (t test, p = 0.036). No side-effects were found. It was concluded that six-monthly applications of chlorhexidine varnish were effective in reducing the incidence of dental caries in primary molars.
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Authors | M Q Du, B J Tai, H Jiang, E C M Lo, M W Fan, Z Bian |
Journal | Journal of dental research
(J Dent Res)
Vol. 85
Issue 6
Pg. 557-9
(Jun 2006)
ISSN: 0022-0345 [Print] United States |
PMID | 16723655
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Topical
- Child, Preschool
- China
- Chlorhexidine
(administration & dosage, therapeutic use)
- DMF Index
- Dental Caries
(prevention & control)
- Double-Blind Method
- Follow-Up Studies
- Humans
- Molar
(drug effects)
- Placebos
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