Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.

Abstract	An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.
Authors	Giuseppe Germano, Martina Pigazzi, Laura del Giudice, Marta Campo Dell'Orto, Monica Spinelli, Andrea Zangrando, Paolo Paolucci, Saverio Ladogana, Giuseppe Basso
Journal	Haematologica (Haematologica) Vol. 91 Issue 5 Suppl Pg. ECR09 (May 2006) ISSN: 1592-8721 [Electronic] Italy
PMID	16709517 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, CD Antigens, Neoplasm Homeodomain Proteins KMT2A protein, human MLL-AF4 fusion protein, human Neoplasm Proteins Oncogene Proteins, Fusion homeobox protein HOXA9 Myeloid-Lymphoid Leukemia Protein Histone-Lysine N-Methyltransferase FLT3 protein, human fms-Like Tyrosine Kinase 3
Topics	Antigens, CD (analysis) Antigens, Neoplasm (analysis) Antineoplastic Combined Chemotherapy Protocols (therapeutic use) B-Lymphocytes (immunology, pathology) Cell Lineage Chromosomes, Human, Pair 11 (genetics, ultrastructure) Chromosomes, Human, Pair 4 (genetics, ultrastructure) Clone Cells (pathology) Combined Modality Therapy Fatal Outcome Female Gene Expression Regulation, Leukemic Gene Rearrangement Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin Hematopoietic Stem Cells (immunology, pathology) Histone-Lysine N-Methyltransferase Homeodomain Proteins (genetics) Humans Immunophenotyping Infant Models, Biological Myeloid-Lymphoid Leukemia Protein (genetics) Neoplasm Proteins (genetics) Oncogene Proteins, Fusion (genetics) Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, genetics, pathology, surgery) Recurrence Translocation, Genetic fms-Like Tyrosine Kinase 3 (genetics)

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