Response to treatment with antihistamines in a family with myotonia congenita.

Abstract

In a family in which myotonia congenita was found in five generations, both great-grandparents of the index case were affected. In subsequent generations mild and severely affected cases were clearly segregated down parallel lines of this family. The grandmother of the index case had noted improvement with an antihistamine. When the index case was prescribed trimeprazine, she showed a striking reduction in severity of symptoms. Antihistamines seem to deserve further evaluation as a safe and effective treatment for myotonia congenita.

• Authors: E F Hughes, J Wilson
• Journal: Lancet (London, England) (Lancet) Vol. 337 Issue 8732 Pg. 28-30 (Jan 05 1991) ISSN: 0140-6736 [Print] England
• PMID: 1670657 (Publication Type: Case Reports, Journal Article)

Chemical References

• Histamine H1 Antagonists
• Trimeprazine
• Antazoline

Topics

• Adult
• Antazoline (therapeutic use)
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Infant
• Male
• Middle Aged
• Myotonia Congenita (drug therapy, genetics)
• Pedigree
• Trimeprazine (therapeutic use)