CAMTA in cardiac hypertrophy.

Abstract

In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5.

• Authors: Robert J Schwartz, Michael D Schneider
• Journal: Cell (Cell) Vol. 125 Issue 3 Pg. 427-9 (May 05 2006) ISSN: 0092-8674 [Print] United States
• PMID: 16678087 (Publication Type: Journal Article, Review, Comment)

Chemical References

• Calcium-Binding Proteins
• Homeobox Protein Nkx-2.5
• Homeodomain Proteins
• NKX2-5 protein, human
• Trans-Activators
• Transcription Factors
• HDAC5 protein, human
• Histone Deacetylases

Topics

• Animals
• Calcium-Binding Proteins (genetics, metabolism)
• Cardiomegaly (genetics, metabolism, physiopathology)
• Heart (growth & development)
• Histone Deacetylases (metabolism)
• Homeobox Protein Nkx-2.5
• Homeodomain Proteins (metabolism)
• Humans
• Myocardium (metabolism, pathology)
• Myocytes, Cardiac (metabolism, pathology)
• Signal Transduction (physiology)
• Trans-Activators (genetics, metabolism)
• Transcription Factors (metabolism)
• Transcriptional Activation (physiology)