Abstract | OBJECTIVE: DESIGN: Prospective, descriptive study. PATIENTS: Thirty-seven singleton pregnant and six twin pregnant women MEASUREMENTS: RESULTS: Serum ghrelin only displayed a minimal, although statistically significant, decrease after CS. Prior to delivery serum PGH increased by 25% during fasting, and was undetectable the day after CS. Serum levels of GH were low until 48 h after CS. No significant correlations were detected between PGH or ghrelin and ISIs, although a trend was observed for ghrelin. Twin pregnancies had higher PGH levels than singletons; however, levels of IGFs were similar. In cord blood, ghrelin levels were higher in arterial than venous samples. CONCLUSIONS: Maternal ghrelin levels were only minimally affected by parturition, suggesting that maternal ghrelin is not involved in the transition from PGH to GH secretion. The increased arterial ghrelin levels in the foetus suggest foetal ghrelin production. Serum PGH appears to be influenced by fasting. Finally, elevated PGH levels in twin pregnancies do not appear to affect maternal IGF levels.
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Authors | Jens Fuglsang, Puk Sandager, Niels Møller, Sanne Fisker, Jan Frystyk, Per Ovesen |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 64
Issue 5
Pg. 502-9
(May 2006)
ISSN: 0300-0664 [Print] England |
PMID | 16649967
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- GH2 protein, human
- Ghrelin
- Insulin
- Peptide Hormones
- Placental Hormones
- Somatomedins
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
- Growth Hormone
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Topics |
- Adult
- Analysis of Variance
- Blood Glucose
(analysis)
- Cesarean Section
- Female
- Gestational Age
- Ghrelin
- Growth Hormone
(blood)
- Humans
- Infant, Newborn
- Insulin
(blood)
- Insulin-Like Growth Factor I
(analysis)
- Insulin-Like Growth Factor II
(analysis)
- Male
- Peptide Hormones
(blood)
- Placental Hormones
(blood)
- Pregnancy
- Pregnancy, Multiple
(blood)
- Prospective Studies
- Somatomedins
(analysis)
- Twins
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