Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases.

Abstract

BACKGROUND/AIMS:

The purpose of the study is to report two long-term survivors with ovarian carcinosarcomas, which are rare intrapelvic malignancies with unfavorable prognosis.

METHODS:

Two middle-aged women with palpable abdominal tumors underwent complete cytoreductive surgery and no macroscopic tumor was left behind. Early postoperative intraperitoneal chemotherapy with doxorubicin was used as an adjuvant treatment.

RESULTS:

The patients are disease-free 2 and 3 years, respectively after the initial therapy.

CONCLUSION:

Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy seems to be an effective treatment for ovarian carcinosarcoma with peritoneal spread. Further studies are required to define the value of intraperitoneal chemotherapy in ovarian carcinosarcoma.

• Authors: A Xanthoulis, Charalambos Mirelis, Sotirios Markakidis, Ioannis Bougioukas, Konstantina Bekiaridou, Evanthia Tsalkidou, Georgios Zafeiropoulos, Antonios-Apostolos K Tentes
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 62 Issue 2 Pg. 100-2 ( 2006) ISSN: 0378-7346 [Print] Switzerland
• PMID: 16645301 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (therapeutic use)
• Carcinosarcoma (drug therapy, surgery)
• Chemotherapy, Adjuvant
• Doxorubicin (therapeutic use)
• Female
• Humans
• Infusions, Parenteral (methods)
• Middle Aged
• Ovarian Neoplasms (drug therapy, surgery)
• Prognosis
• Survivors
• Treatment Outcome