Abstract |
Tobacco smoke and ionizing radiation induce oxidative stress by transmitting or generating reactive oxygen species (ROS). We hypothesized that glutathione-S-transferase M1 (GSTM1) null homozygotes would have decreased ability to neutralize ROS that might increase their susceptibility to lung cancer. A case-only design was used with lung cancer cases pooled from 3 previously completed case-control studies using archival tissue samples from 270 lung cancer cases to genotype GSTM1. Radon concentrations were measured with long-term alpha-track radon detectors. Secondhand smoke (SHS) was measured with questionnaires and interviews. Unconditional logistic regression was used to calculate the interaction odds ratios (OR) and 95% confidence intervals (95% CI). Radon concentrations >121 Bq m(-3) were associated with a >3-fold interaction OR (OR = 3.41; 95% CI = 1.10, 10.61) for GSTM1 null homozygotes compared to GSTM1 carriers; the linear trend was significant (p trend = 0.03). The SHS and GSTM1 interaction OR was also elevated (OR = 2.28; 95% CI = 1.15-4.51) among never-smokers. This may be the first study to provide evidence of a GSTM1 and radon interaction in risk of lung cancer. Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway.
|
Authors | Matthew R Bonner, William P Bennett, Wenying Xiong, Qing Lan, Ross C Brownson, Curtis C Harris, R William Field, Jay H Lubin, Michael C R Alavanja |
Journal | International journal of cancer
(Int J Cancer)
Vol. 119
Issue 6
Pg. 1462-7
(Sep 15 2006)
ISSN: 0020-7136 [Print] United States |
PMID | 16642467
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Tobacco Smoke Pollution
- Glutathione Transferase
- glutathione S-transferase M1
- Radon
|
Topics |
- Aged
- Environmental Exposure
- Female
- Genotype
- Glutathione Transferase
(genetics)
- Humans
- Lung Neoplasms
(enzymology, genetics)
- Odds Ratio
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Radon
(adverse effects)
- Research Design
- Risk Factors
- Tobacco Smoke Pollution
(adverse effects)
|