[Therapy of systemic mycoses in neutropenic patients using itraconazole. A comparative, randomized study with amphotericin B].

Abstract

Systemic mycosis constitute a serious threat for the patient with granulocytopenia. The most important causative agents are Candida spp., Aspergillus spp. and, to a lesser extent, Cryptococcus neoformans, Mucoraceae and Pseudoallescheria boydii. Treatment of such infections with amphotericin B is difficult, because of the many side-effects of this medicine, such as hypotension, fever, shivering, thrombophlebitis, nephrotoxicity, renal tubular acidosis, hypokalaemia, anaemia and thrombocytopenia. In addition, the efficacy of amphotericin B in the treatment of proven mycotic infections in granulocytopenic patients is not very great. Itraconazole is a new, oral antifungal agent which is active in vitro and in animal experiments against both Candida and Aspergillus. In patients without granulocytopenia, itraconazole appeared to be effective in the treatment of deep Candida and Aspergillus infections. On the basis of the above data, a randomized comparative investigation was carried out unto the efficacy of amphotericin B and itraconazole in the treatment of systemic mycoses in neutropenic patients.

• Authors: J W van't Wout, I Novakova, C A Verhagen, W E Fibbe, B E de Pauw, J W van der Meer
• Journal: Medizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)) Vol. 86 Suppl 1 Pg. 11-3 (Dec 1991) ISSN: 0723-5003 [Print] Germany
• Vernacular Title: Die Therapie von Systemmykosen neutropenischer Patienten mit Itraconazol. Eine vergleichende, randomisierte Studie mit Amphotericin B.
• PMID: 1663200 (Publication Type: Case Reports, Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Itraconazole
• Amphotericin B
• Ketoconazole

Topics

• Adolescent
• Agranulocytosis (complications)
• Amphotericin B (therapeutic use)
• Antifungal Agents (therapeutic use)
• Aspergillosis, Allergic Bronchopulmonary (drug therapy)
• Candidiasis (drug therapy)
• Humans
• Itraconazole
• Ketoconazole (analogs & derivatives, therapeutic use)
• Male
• Mycoses (complications, drug therapy)