Abstract | BACKGROUND: METHODS: In a randomized double-blind study, we investigated 120 children aged 1-12 years undergoing general anesthesia for tonsillectomy or adenotonsillectomy. Patients received 0.1 mg x kg(-1) tropisetron (maximum 2 mg) immediately after inhalational induction (early) and establishment of intravenous access or after the end of surgery before extubation (late). PONV and the need for antiemetic rescue medications were recorded within the following 48 h. Patient data were analyzed using t-test, chi-squared test (significance level of alpha = 0.05) and Spearman rank correlation test. RESULTS: The overall incidence of vomiting was 55.3%, with 60% (36/60) in the early treatment and 51.6% (31/60) in the late treatment group (P = 0.46). The observed time course 48 h postoperatively showed no difference regarding the number of vomiting episodes between the two groups and the need for antiemetic rescue medication. The incidence of nausea was higher in the late application group in the first 6 h after extubation (P = 0.001) and higher in the early application group between 24 and 48 h after extubation (P = 0.02). Morphine and the age over 3 years had a strong influence on the incidence of vomiting. CONCLUSION:
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Authors | Dominique Gross, Suzanne Reuss, Claudia M Dillier, Andreas C Gerber, Markus Weiss |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 16
Issue 4
Pg. 444-50
(Apr 2006)
ISSN: 1155-5645 [Print] France |
PMID | 16618300
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiemetics
- Indoles
- Tropisetron
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Topics |
- Adenoidectomy
- Anesthesia, General
- Antiemetics
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Humans
- Indoles
(administration & dosage, therapeutic use)
- Infant
- Intraoperative Period
- Male
- Postoperative Nausea and Vomiting
(epidemiology, prevention & control)
- Time Factors
- Tonsillectomy
- Tropisetron
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