Abstract | AIMS: METHODS: Cell proliferation was evaluated by MTT assay, MMP activity by gelatinase zymography, and invasion through Matrigel. RESULTS: Human ovarian cancer cell growth was not significantly affected by the NM. Zymography demonstrated inhibition of MMP-2 secretion in a dose-dependent fashion with virtual total inhibition at 50 microg/mL NM concentration. Invasion of human ovarian cancer cells through Matrigel decreased in a dose-dependent fashion, with 90% inhibition at 500 microg/mL NM and 100% inhibition at 1000 microg/mL NM (P < 0.0001). CONCLUSION:
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Authors | M Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 32
Issue 2
Pg. 148-54
(Apr 2006)
ISSN: 1341-8076 [Print] Australia |
PMID | 16594917
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids
- Enzyme Inhibitors
- Matrix Metalloproteinase Inhibitors
- Tea
- Arginine
- Proline
- Matrix Metalloproteinase 2
- Lysine
- Ascorbic Acid
|
Topics |
- Amino Acids
(pharmacology)
- Arginine
(pharmacology)
- Ascorbic Acid
(pharmacology)
- Cell Division
(drug effects)
- Cell Line, Tumor
- Enzyme Inhibitors
(pharmacology)
- Female
- Humans
- Lysine
(pharmacology)
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase Inhibitors
- Neoplasm Invasiveness
(prevention & control)
- Ovarian Neoplasms
(enzymology, pathology, prevention & control)
- Proline
(pharmacology)
- Tea
(chemistry)
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