Abstract | BACKGROUND: METHODS: RESULTS: Of the 3363 black subjects examined, 2.6 percent had nonsense mutations in PCSK9; these mutations were associated with a 28 percent reduction in mean LDL cholesterol and an 88 percent reduction in the risk of CHD (P=0.008 for the reduction; hazard ratio, 0.11; 95 percent confidence interval, 0.02 to 0.81; P=0.03). Of the 9524 white subjects examined, 3.2 percent had a sequence variation in PCSK9 that was associated with a 15 percent reduction in LDL cholesterol and a 47 percent reduction in the risk of CHD (hazard ratio, 0.50; 95 percent confidence interval, 0.32 to 0.79; P=0.003). CONCLUSIONS: These data indicate that moderate lifelong reduction in the plasma level of LDL cholesterol is associated with a substantial reduction in the incidence of coronary events, even in populations with a high prevalence of non- lipid-related cardiovascular risk factors.
|
Authors | Jonathan C Cohen, Eric Boerwinkle, Thomas H Mosley Jr, Helen H Hobbs |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 354
Issue 12
Pg. 1264-72
(Mar 23 2006)
ISSN: 1533-4406 [Electronic] United States |
PMID | 16554528
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2006 Massachusetts Medical Society. |
Chemical References |
- Cholesterol, LDL
- Codon, Nonsense
- PCSK9 protein, human
- Proprotein Convertase 9
- Proprotein Convertases
- Serine Endopeptidases
|
Topics |
- Black People
(genetics)
- Carotid Arteries
(anatomy & histology)
- Cholesterol, LDL
(blood)
- Codon, Nonsense
- Cohort Studies
- Coronary Disease
(blood, epidemiology, genetics)
- Female
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Hypolipoproteinemias
(genetics)
- Incidence
- Male
- Middle Aged
- Proportional Hazards Models
- Proprotein Convertase 9
- Proprotein Convertases
- Risk
- Serine Endopeptidases
(genetics)
- United States
- White People
(genetics)
|