Abstract | PURPOSE: The aim of this study was to determine the safety and pathologic response rates following neoadjuvant paclitaxel and radiation in patients with stage II/III breast cancer and to evaluate the use of sequential biopsies to allow an in vivo assessment of biological markers as potential predictive markers of response to this regimen. PATIENTS AND METHODS: RESULTS: Of the 38 patients enrolled, 13 (34%) had a pathologic complete response. There was no significant difference in baseline Ki-67 between responders (35%) and nonresponders (28%; P = 0.45). There was also no significant change in Ki-67 following paclitaxel administration. Despite this lack of immunohistologic change in proliferative activity, baseline mitotic index was higher for patients with pathologic complete response over nonresponders (27 versus 10, P = 0.003). Moreover, the increase in mitotic index following paclitaxel administration was associated with pathologic complete response. CONCLUSIONS: Neoadjuvant paclitaxel/radiation is effective and well tolerated. Tumor proliferation at baseline and response to chemotherapy as measured by mitotic activity may serve as an important indicator of pathologic response to neoadjuvant paclitaxel/radiation.
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Authors | A Bapsi Chakravarthy, Mark C Kelley, Bernadette McLaren, Cristina I Truica, Dean Billheimer, Ingrid A Mayer, Ana M Grau, David H Johnson, Jean F Simpson, R Daniel Beauchamp, Catherine Jones, Jennifer A Pietenpol |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 12
Issue 5
Pg. 1570-6
(Mar 01 2006)
ISSN: 1078-0432 [Print] United States |
PMID | 16533783
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Biomarkers, Tumor
- Paclitaxel
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Topics |
- Adult
- Aged
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(drug therapy, radiotherapy, surgery)
- Combined Modality Therapy
- Female
- Gamma Rays
- Humans
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Paclitaxel
(therapeutic use)
- Radiotherapy Dosage
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