Circulating adiponectins have multiple protective roles as anti-diabetic, anti-atherosclerotic, and anti-inflammatory factors. We examined the relationship between plasma
adiponectin concentration and other cardiovascular risk in nondiabetic
coronary artery disease (CAD) men and the relationship can be maintained even after adjusted for major environmental factors that contribute to
adiponectin concentrations.
METHODS: Nondiabetic CAD men (n=613) were 31-70 y and had body mass index (BMI) of 18.5-29.9 kg/m2.
RESULTS: Circulating adiponectins positively correlated with age and negatively with BMI, waist circumference and % body fat (p-values of all <0.001). Plasma
adiponectin concentrations were higher in never-smokers (5.07+/-0.30 microg/ml) than current (4.15+/-0.12 microg/ml) and ex-smokers (3.75+/-0.20 microg/ml) both before and after adjusted for age and adiposity (p=0.002 and p=0.008, respectively), however they were not significantly different according to alcohol drinking status. After adjusted for age, adiposity and cigarette smoking, plasma
adiponectin still have positive correlations with
HDL cholesterol,
apolipoprotein AI and
LDL particle size, and inversely with fasting
triglyceride, atherogenic index,
insulin resistance and
C-reactive protein (CRP). However there was no significant relationships between
adiponectin and
apolipoprotein B, total
cholesterol or
LDL cholesterol. In subset analysis by tertile
adiponectin concentrations (lowest: <2.92, moderate: 2.92<or=
adiponectin<4.75, highest: >or=4.75 microg/ml), 'moderate' and 'highest'
adiponectin groups had lower
triglyceride (p<0.001), lower atherogenic index (p=0.001), lower fasting
insulin (p=0.004), lower
insulin resistance (p=0.001), lower CRP (p=0.001), higher
HDL cholesterol (p<0.001), higher
apolipoprotein AI (p=0.005) and higher
LDL particle size (p<0.001) as compared with 'lowest'
adiponectin group when adjusted for age, adiposity and cigarette smoking. Platelets were lower in 'highest'
adiponectin groups as compared with 'lowest' and 'moderate'
adiponectin group after the adjustment. However, there was no significant difference in total
cholesterol (p=0.145),
LDL cholesterol (p=0.145),
apolipoprotein B (p=0.222) and fasting
glucose (p=0.157).
CONCLUSION: