Abstract | BACKGROUND: Persons with Down syndrome have increased vulnerability to oxidative stress caused by overexpression of superoxide dismutase, an antioxidant enzyme coded on chromosome 21. Increased oxidative stress may lead to oxidative damage of important macromolecules. We monitored this damage by measuring levels of different biomarkers of oxidative stress (protein carbonyls and 4-hydroxy-2-nonenal), as well as plasma antioxidant capacity, in children with Down syndrome. A total of 20 children with Down syndrome and 18 healthy individuals were recruited for this purpose. METHODS: RESULTS: CONCLUSION: Our results on oxidative damage to proteins confirm the assumption of increased oxidative stress in individuals with Down syndrome.
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Authors | Ingrid Zitnanová, Peter Korytár, Hana Sobotová, L'ubica Horáková, Mária Sustrová, Siegfried Pueschel, Zdenka Duracková |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 44
Issue 3
Pg. 306-10
( 2006)
ISSN: 1434-6621 [Print] Germany |
PMID | 16519603
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Aldehydes
- Antioxidants
- Biomarkers
- Proteins
- Superoxide Dismutase
- 4-hydroxy-2-nonenal
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Topics |
- Aldehydes
(blood)
- Antioxidants
(analysis)
- Biomarkers
(blood)
- Child
- Child, Preschool
- Down Syndrome
(blood, diagnosis)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Oxidative Stress
(physiology)
- Protein Carbonylation
(physiology)
- Proteins
(analysis, chemistry)
- Superoxide Dismutase
(blood)
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