Abstract | OBJECTIVES: METHODS: HIV-infected patients receiving HAART who had lipodystrophy (LIPO, n=18) or were without lipodystrophy (NONLIPO, n=18) were investigated. Insulin sensitivity (M-value), glucose oxidation rate (GOX) and fasting endogenous glucose production (EGP) were determined by hyperinsulinemic euglycemic clamp, indirect calorimetry and glucose tracer technique, respectively. RESULTS: Fasting p- lactate (median 1.2 mmol/L; range 0.6-4.3, n=36) tended to be increased in LIPO (P=0.12); 6 patients (4 LIPO) had lactate > or =2.0 mmol/L. Fasting lactate correlated inversely with M-value (P<0.001) and positively with fasting EGP (P<0.05) and fasting GOX (P<0.05), together explaining 51% (R2, n=36) of the variation in fasting lactate. Lactate increased in NONLIPO (P<0.05) but not in LIPO (P>0.5) during clamp. Incremental (clamp minus fasting value) GOX (P<0.01) was decreased and incremental insulin (P<0.01) was increased in LIPO. CONCLUSIONS:
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Authors | Steen B Haugaard, Ove Andersen, Sten Madsbad, Johan Iversen, Flemming Dela |
Journal | The Journal of infection
(J Infect)
Vol. 54
Issue 1
Pg. 89-97
(Jan 2007)
ISSN: 1532-2742 [Electronic] England |
PMID | 16487595
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-HIV Agents
- Lactic Acid
- Glucose Oxidase
- Glucose
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Topics |
- Adult
- Anti-HIV Agents
(adverse effects)
- Antiretroviral Therapy, Highly Active
- Glucose
(metabolism)
- Glucose Clamp Technique
- Glucose Oxidase
(analysis)
- HIV Infections
(blood, drug therapy, metabolism)
- Humans
- Insulin Resistance
- Lactic Acid
(blood)
- Middle Aged
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