[Changes in hemostasis at aortic surgery under conditions of extracorporeal circulation].

Abstract

This paper describes hemostatic changes in patients who had undergone aortic surgery under conditions of extracorporeal circulation. The changes in the hemostatic system are marked by the thrombophilic condition made up for activation ox blood fibrinolytic activity in the preoperative period. The basic amount of blood loss falls within the first 6 hours after operation. Prolonged hypothermic extracorporeal circulation and the high intraoperative blood loss (over 35 ml/kg bw) lead to an appreciable decrease in antithrombin III and protein C activity which results in activation of disseminated intravascular blood coagulation in the early postoperative period and ineffectiveness of heparin therapy. Secondary hyperfibrinolysis together with combined thrombocytopenia and platelet dysfunction are the basic causes of higher than usual bleeding in patients after aortic surgery under conditions of extracorporeal circulation.

• Authors: M A Charnaia, Iu A Morozov, V G Gladysheva, E V Roĭtman, A M Isaeva, Iu V Belov, A V Goncharova
• Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery (Angiol Sosud Khir) Vol. 11 Issue 4 Pg. 27-31 ( 2005) ISSN: 1027-6661 [Print] Russia (Federation)
• PMID: 16474289 (Publication Type: English Abstract, Journal Article)

Chemical References

• Protein C
• Antithrombin III

Topics

• Antithrombin III (analysis)
• Aorta (surgery)
• Aorta, Thoracic (surgery)
• Aortic Valve (surgery)
• Blood Loss, Surgical
• Blood Platelets (physiology)
• Blood Vessel Prosthesis
• Extracorporeal Circulation
• Female
• Heart Valve Prosthesis Implantation
• Hemostasis
• Humans
• Male
• Middle Aged
• Postoperative Period
• Protein C (analysis)
• Thrombocytopenia (complications)
• Time Factors